Phosphatidylethanolamine Enhances Amyloid Fiber Dependent Membrane Fragmentation
نویسندگان
چکیده
منابع مشابه
Fibril Fragmentation Enhances Amyloid Cytotoxicity*♦
Fibrils associated with amyloid disease are molecular assemblies of key biological importance, yet how cells respond to the presence of amyloid remains unclear. Cellular responses may not only depend on the chemical composition or molecular properties of the amyloid fibrils, but their physical attributes such as length, width, or surface area may also play important roles. Here, we report a sys...
متن کاملNeuronal membrane cholesterol loss enhances amyloid peptide generation
Recent experimental and clinical retrospective studies support the view that reduction of brain cholesterol protects against Alzheimer's disease (AD). However, genetic and pharmacological evidence indicates that low brain cholesterol leads to neurodegeneration. This apparent contradiction prompted us to analyze the role of neuronal cholesterol in amyloid peptide generation in experimental syste...
متن کاملNylon-fiber-induced neutrophil fragmentation.
We have investigated the effects of mechanical elution of neutrophils from nylon-wool fiber (NWF) using the scanning electron microscope and biochemical analysis of elution fractions. We have determined that mechanical removal of neutrophils from nylon-wool fiber disrupts neutrophils adherent to nylon-wool fiber and augments release of granules, release of peripheral cytoplasmic fragments, and ...
متن کاملSpin-dependent Fragmentation Functions
A confusing variety of new and exotic fragmentation functions (FFs) is discussed recently, in particular in the context of the extraction of the third, leading twist – hitherto unknown – nucleon distribution function. This transversity distribution h1(x) (frequently also denoted δq(x) or ∆Tq(x)) involves a flip of quark chirality, and therefore, requires a second chiral-odd function to form a c...
متن کاملAsymmetric metabolism of phosphatidylethanolamine in the human red cell membrane.
The incorporation of labeled fatty acids into phosphatidylethanolamine (PE) on the two sides of the human red cell membrane was studied by use of the vectorial probe trinitrobenzene sulfonate (TNBS). A small population of PE molecules on the outer surface of the membrane has a 4-fold higher turnover rate than the remaining PE molecules. This effect is greatest with palmitic acid, less with lino...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2012
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2011.11.2677